Dr. Sajal Ghosh | Department of Physics

Profile

Dr. Sajal
Kumar
Ghosh
Associate Professor
Department of Physics
School of Natural Sciences (SNS)
A017D, Shiv Nadar University
Dadri Uttar Pradesh
India
91-0120-7170100
Extn: 
410
Profile Summary 

Dr. Sajal Kumar Ghosh did his Ph.D. from Raman Research Institute, Bangalore, India. There after he joined as a post-doctoral scientist in the Institute for X-ray Physics, University of Goettingen, Germany. Then he moved to the University of California-San Diego (UCSD), California, USA to work as a post-doctoral scholar. Sajal has research experience in the field of soft matter physics including bio-physics. He has presented his research works in many international conferences in India, Japan, Germany, Italy, France, Spain, UK and USA. His present interests are in i) tuning viscoelastic properties of soft materials by altering the self-assembled aggregates, ii) developing simple model systems to facilitate physical and chemical studies of bio-systems, iii) developing devices which are useful for drug delivery, bio-sensing, non-destructive molecule counter etc. using nanotechnologies.

 
Educational Qualifications 
2008
Ph.D.
Raman Research Institute, Bangalore, (Jawaharlal Nehru University, New Delhi)
2001
M.Sc
Department of Physics, University of Kalyani, West Bengal.
1999
B.Sc
Department of Physics, University of Kalyani, West Bengal.
Work Experience 
06/20Present
Associate Professor,
Department of Physics, School of Natural Sciences, Shiv Nadar University, Delhi-NCR
I currently work here
11/13
05/20
Assistant Professor,
Department of Physics, School of Natural Sciences, Shiv Nadar University, Delhi-NCR
09/10
10/13
Post-doctoral Scholar,
Department of Physics, University of California- San Diego, USA.
03/08
08/10
Post-doctoral Scientist,
Department of Physics, University of Goettingen, Germany
Teaching & Research Interests: 

TEACHING:             

  • PHY 252: Introduction to BioPhysics (Undergraduate Course)
  • PHY 569: Complex Fluids (Graduate Course)
  • PHY 108: Physics for life: A fundamental course (Undergraduate Course)
  • PHY 103: Fundamental of Physics – I (Undergraduate Course)
  • PHY 101: Introduction to Physics I (Undergraduate Course for Engineering Major)
  • PHY 572: Soft Matter Physics (Graduate Course)
  • CCC 417: Physical Laws: from Nonliving to Living (Undergraduate Course)

RESEARCH 
We work in the field of experimental soft matter physics including biophysics. Soft materials used in cosmetic industries are investigated to explore their underlying structures and corresponding viscoelastic properties. These structures are altered by tuning the electrostatic interaction among the self-assembled aggregates in amphiphilic systems. In turn, the materials show interesting physical properties which are important for industrial applications. We also work in the field of membrane biophysics to develop model systems to investigate the interaction of macromolecules (e.g. protein, DNA etc.) with model cellular membranes. We are now embarking on to develop devices for bio-medical applications using nano-technology. Different x-ray scattering (x-ray diffraction, x-ray reflectivity, grazing incidence x-ray diffraction etc.) and microscopy techniques are used at in-house and international synchrotron facilities to study the structures and properties of such soft materials and bio-systems. 

Laboratory: Click here for laboratory details

Research in Media:

 

RESEARCH STUDENTS   

Ph. D students: Supervising

  1. Prashant Hitaishi : DST-SERB funded                                                 
  2. Gunjan Sharma         
  3. Ajit Seth         
  4. Rumal Singh                                                                                                                                            

Ph. D students: Co-supervising

  1. Yogesh Yadav 
  2. Devansh Kaushik 

Group Alumni:

PhD Completed:

Former UG Research Students

  • Preethi Sradha, Arjun Bhasker, Siddharth Rao, Meet Raval, Anamaya Shah, Aishwarya Sathya, Shuverthi De Sarkar, Uttam Italia, Nandita Singhal
Conferences (Select): 
  1. Synchrotron X-rays and Neutron Scattering Studies of Anti-bacterial activities of Imidazolium-based Ionic Liquids, 63rd DAE-Solid State Physics Symposium, December 2018, Guru Jambheshwar University of Science and Technology, Hisar, India.
  2.  Effect of imidazolium-based ionic liquids on the structure and dynamics of cellular membrane: From model to mammalian membranes, November 2018, Department of Physics, University of Goettingen, Germany
  3. Self-assembled structures of soft-materials by synchrotron x-ray scattering, December 2017, Discussion meeting on Synchrotron Science, Saha Institute of Nuclear Physics, Kolkata, India
  4. Interaction of imidazolium-based ionic liquids with soft supported lipid membrane, 19th IUPAB and 11th EBSA Congress Edinburgh, July 2017, UK
  5. Soft supported lipid bilayer to study cellular membrane, May 2015, Institute of Materials Structure Science, High Energy Accelerator Research Organization [Tokai Campus], Japan
  6. Structural studies of lipid-protein interactions on cushioned bilayers, March, 2013, APS March Meeting 2013, Baltimore, MD, USA
  7. Highly resolved structure of a floating lipid bilayer: Effect of Ca2+ ions and temperature, February 2013, 57th Annual Meeting of Biophysical Society, Philadelphia, USA
  8. Interaction of Synaptic Vesicles with Model Lipid Membranes: A Structural Study, July 2010, International Soft Matter Conference 2010, Granada, Spain
  9. Interaction of Synaptic Vesicles with Lipid Monolayers: A Structural Investigation by X-ray Reflectivity and GIXD, November 2009, Jülich Soft Matter Days 2009, Bonn, Germany
Awards(Selected): 
2017

DST travel and experimentg grant to perform experiment in PETRA III, Hamburg, Germany in November 2018

2014

DST travel & experiment grants to perform synchortron experiments in Photon Factory (PF), KEK, Tsukuba, Japan: June 2015, November 2015, February 2017, April 2017, February 2018 & June 2018.

2015

DST travel grant to attend 19th International Union of Pure and Applied Biophysics (IUPAB) and 11th European Biophysical Societies' Association (EBSA) Congress in Edinburgh, Scotland.

2001

Scored in Joint Entrance Screening Test (JEST) in 2002 and research fellowship was awarded.

2000

Qualified Graduate Aptitude Test in Engineering (GATE) 

1998

Merit scholarship by University of Kalyani for ranking first in BSc.

Scholarly Activity

Journal Articles

2022

44. P. Hitaishi, A. Seth, S. Mitra and S. K. Ghosh; Thermodynamics and in-plane viscoelasticity of anionic phospholipid membranes modulated by an ionic liquid, Pharmaceutical Research (2022), Accepted for publication.

43. P. Mandal, S. K. Ghosh and H. S. Grewal; Graphene oxide coated aluminium as an efficient antibacterial surface, Environmental Technology & Innovation (2022) 28, 102591

42. R. Gupta, V. K. Sharma, J. Gupta and S. K. Ghosh; 1, 3 dialkylated imidazolium ionic liquid causes interdigitated domains in a phospholipid membrane, Langmuir (2022), 38, 11, 3412–3421

41. P. Mandal, J. Ivvala, H. S. Arora, Harpreet, S. K. Ghosh and H. S. Grewal; Bioinspired Micro/nano Structured Aluminium with Multifaceted Applications, Colloids and Surfaces B: Biointerfaces (2022), 211, 112311

2021

40. P. Hitaishi, P. Mandal and S. K. Ghosh; Partitioning of a Hybrid Lipid in Domains of Saturated and Unsaturated Lipids in a Model Cellular Membrane, ACS Omega (2021), 6, 50, 34546 -34554

39. P. Mandal, R. P. Giri, B. Murphy and S. K. Ghosh; Self-assembly of Graphene Oxide Nano-flakes in Lipid Monolayer at Air-water Interface, ACS Applied Materials and Interfaces (2021), 13, 57023-57035

38. R. Gupta, J. Kumari, S. Pati, S. Singh, M. Mishra, S. K. Ghosh, Interaction of cyclotide Kalata B1 protein with model cellular membranes of varied electrostatics, International Journal of Biological Macromolecules (2021) 191, 852–860

37. P. Mandal, J. Ivvala, H. S. Arora, H. S. Grewal, S. K. Ghosh, Structured aluminium surfaces with tunable wettability fabricated by a green approach, Materials Letters (2021), 300, 130186

36. R. Gupta, S. Mitra, S. Chowdhury, G. Das, R. Priyadarshini, M. Mukhopadhyay and S. K. Ghosh, Discerning perturbed assembly of lipids in a model membrane induced by violacein, BBA - Biomembranes (2021), 1863,183647        

35. Y. Yadav, S. K. Ghosh and S. P. Singh, High-performance Organic Field-effect Transistors Gated by Imidazolium-based Ionic Liquids; ACS Applied Electronic Materials (2021), 3, 1496−1504 

34. S. Mitra, V. K. Sharma, J. B. Mitra, S. Chowdhury, M. K. Mukhopadhyay, R. Mukhopadhyay and S. K. Ghosh; Thermodynamics and structure of model bio-membrane of liver lipids in presence of imidazolium-based ionic liquids, BBA - Biomembranes (2021), 1863, 183589 

33. R. Gupta, A. Singh, V. Srihari, and S. K. Ghosh; Ionic Liquid-Induced Phase-Separated Domains in Lipid Multilayers Probed by X‑ray Scattering Studies; ACS Omega (2021), 6, 4977-4987

32. P. Mandal, G. Bhattacharya, A. Bhattacharyya, S. S. Roy and S. K. GhoshUnravelling the Structural Changes of Phospholipid Membranes in Presence of Graphene Oxide, Applied Surface Science (2021), 539, 148252 

31. P. Mandal, G. Perumal, H. S. Arora, S. K Ghosh and H. S. Grewal, Green Manufacturing of Nanostructured Al-Based Sustainable and Self-cleaning Metallic Surface , Journal of Cleaner Production(2021), 278, 123373 

2020

30. R. Karim, D. Panda, A. Adhikari, P. Haldar, P. Mandal, S. K. Ghosh, S. Bedanta, A. Barman, and I. Sarkar, Electrodeposited Heusler alloy films with enhanced magneto-optical property, Materials Today Communications (2020), 25, 101678.

29. V. K. Sharma, S. K Ghosh, V. G. Sakai and R. Mukhopadhyay, Enhanced Microscopic Dynamics of a Liver Lipid Membrane in the Presence of an Ionic Liquid, Frontiers in Chemistry (2020), 8, 577508 

28. S. D. Sarkar, S. Mitra and S. K. Ghosh, Relating the Physical Properties of Aqueous Solutions of Ionic Liquids with Their Chemical Structures, European Physical Journal - E (2020) , 43, 55 

27. P. Mandal, A. Shishodia, N. Ali, S. Ghosh, H. S. Arora, H. S. Grewal, and S. K. Ghosh, Effect of topography and chemical treatment on the hydrophobicity and antibacterial activities of micropatterned aluminium surfaces, Surface Topography: Metrology and Properties (2020) , 8, 025017 

26. S. Mitra, R. Das, A. Singh; M. K. Mukhopadhyay, G. Roy, and S. K.Ghosh, Surface activities of a lipid-analogue room temperature ionic liquid and its effects on phospholipid membrane, Langmuir (2020), 36, 328- 339 

25. K. Bakshi, S. Mitra, V. K. Sharma, M. S. K. Jayadev, V. G. Sakai, R. Mukhopadhyay, A. Gupta and S. K. Ghosh, Imidazolium-based ionic liquids cause mammalian cell death due to modulated structures and dynamics of cellular membrane, BBA-Biomembranes (2020), 1862, 183103

2019 - 2005

24. S. Mitra, R. Karri, P. K Mylapalli, A. B. Dey, G. Bhattacharya, G. Roy, S. M. Kamil, S. Dhara, S. K. Sinha and S. K. Ghosh, Re-entrant Direct Hexagonal Phases in a Lyotropic System of Surfactant Induced by an Ionic Liquid, Liquid Crystal (2019), 46:9, 1327-1339 

23. J.-Jin Song, R. Bhattacharya, Y. Yang, S. K. Ghosh, S. K. Sinha, H. Kim, J. Chang, H. Kim, T. P. Russell, T. Tang, G. Arya, H. Guo, S. Narayanan and Z. Jiang, One-Dimensional Anomalous Diffusion of Gold Nanoparticles in a Polymer Melt, Physical Review Letters (2019), 122, 107802 

22. S. B. Srivastava, M. H. Modi, S. K. Ghosh and S. P. Singh, Investigation of the buried planar interfaces in multi-layered inverted organic solar cells using X-ray reflectivity and impedance spectroscopy, Journal of Physics-Condensed Matter (2019) 31(12):124003 

21. S. Mitra, D. Ray, G. Bhattacharya, R. Gupta, D. Sen,V. K. Aswal and S. K. Ghosh, Probing the effect of a room temperature ionic liquid on phospholipid membranes in multilamellar vesicles, European Biophysics Journal (2019) 48(2):119-129 

20. G. Bhattacharya, R. P. Giri, A. Dubey, S. Mitra, R. Priyadarshni, A. Gupta, M. K. Mukhopadhyay and S. K. Ghosh, Structural changes in cellular membranes induced by ionic liquids: From model to bacterial membranes, Chemistry & Physics of Lipids (2018), 215, 1-10  

19. G. Bhattacharya, S. Mitra, P. Mandal, S. Dutta, R. P. Giri and S. K. Ghosh; Thermodynamics of interaction of ionic liquids with lipid monolayer; Biophysical Reviews (2018), 10, 709-719 

18. A. Barman, C. P. Saini, P. K. Sarkar, G. Bhattacharjee, G. Bhattacharya, S. Srivastava, B. Satpati, D. Kanjilal, S. K. Ghosh, S. Dhar, and A. Kanjilal; Resistive switching behavior in oxygen ion irradiated TiO2-x films; J.Phys. D: Appl Phys (2018),51, 065306  

17. V. K. Sharma, S. K. Ghosh, P. Mandal, T. Yamada, K. Shibata, S. Mitra and R. Mukhopadhyay; Effects of ionic liquids on the nanoscopic dynamics and phase behaviour of a phosphatidylcholine membrane. Soft Matter (2017), 13, 8969.    

16. G. Bhattacharya, R. P. Giri, H. Saxena, V. V. Agrawal, A. Gupta, M. K. Mukhopadhyay and S. K. Ghosh; X-ray Reflectivity Study of the Interaction of an Imidazolium-Based Ionic Liquid with a Soft Supported Lipid Membrane, Langmuir (2017), 33, 1295-1304 

15. R. P. Giri, M K. Mukhopadhyay, M. Mitra, A. Chakrabarti, M. K. Sanyal, S. K. Ghosh, S. Bera, L. B. Lurio, Y. Ma and S. K. Sinha; Differential adsorption of a membrane skeletal protein, spectrin, in phospholipid membranes; Euro Phys. Lett. (2017), 118, 58002 

14. A. Barman, C. P. Saini, P. K. Sarkar, A. Roy, B. Satpati, D. Kanjilal, S. K. Ghosh, S. Dhar, and A. Kanjilal, Probing electron density across Ar+ irradiation-induced self-organized TiO2-xnanochannels for memory application, Applied Physics Letters (2016) 108, 244104   

13. Y. Ma, S. K. Ghosh, D. A. DiLena, S. Bera, L. B. Lurio, A. N. Parikh, and S. K. Sinha, Cholesterol Partition and Condensing Effect in Phase-Separated Ternary Mixture Lipid Multilayers. Biophysical Journal (2016), 110, 1355-1366.

12. Y. Ma, S. K. Ghosh, S. Bera, Z. Jiang, C. M. Schleputz, E. Karapetrova, L. B. Lurio and S. K. Sinha Anomalous partitioning of water in coexisting liquid phases of lipid multilayers near 100% relative humidity. Phys.Chem.Chem.Phys., (2016), 18, 1225-1232

11. Y. Ma, S. K. Ghosh, S. Bera, Z. Jiang, S. Tristram-Nagle, L. B. Lurio and S. K. Sinha, Accurate calibration and control of relative humidity close to 100% by X-raying a DOPC multilayer. Phys. Chem. Chem. Phys. (2015), 17, 3570-3576.

10. S. K. Ghosh, B. Salgin, D. Pontoni, T. Reusch, P. Keil, D. Vogel, M. Rohwerder, H. Reichert, and T. Salditt, Structure and volta potential of lipid multilayers: Effect of x-ray irradiation, Langmuir (2013), 29, 815-824.

9. A. V. Radhakrishnan, S. K. Ghosh, G. Pabst, V. A. Raghunathan & A. K. Sood, Tuning DNA-amphiphile condensate architecture with strongly binding counterions Proc. Natl. Acad. Sci (PNAS), USA. (2012), 109, 6394-6398

8. S. K. Ghosh, S. Castorph, O. Konovalov, R. Jahn, T. Salditt, M. Holt, Measuring Ca2+ induced structural changes in lipid monolayers: implication for synaptic vesicles Exocytosis, Biophysical Journal, (2012), 102, 1394-1402

7. S. K. Ghosh, S. Aeffner and T. Salditt, Effect of PIP2 on DOPC bilayer structure and phase behavior: An x-ray scattering study ChemPhysChem, (2011), 12, 2633-2640

6. S. K. Ghosh, S. Castorph, O. Konovalov, R. Jahn, M. Holt and T. Salditt, In vitro study of interaction of synaptic vesicles with lipid membranes.; New J. Phys. (2010), 12, 105004

5. S. Castorph, L. Arleth, M. Sztucki, U. Vainio, S. K. Ghosh, R. Jahn, M. Holt and T. Salditt, Synaptic Vesicles Studied by SAXS: Derivation and Validation of a Model Form Factor J. Phys.: Conf. Ser. (2010), 247, 012015

4. S. K. Ghosh, V. Rathee, R. Krishnaswamy, V. A. Raghunathan & A. K. Sood, Re-entrant Phase Behaviour of a Concentrated Anionic Surfactant System with Strongly Binding Counterions,Langmuir (2009), 25, 8497-8506.

3. S. K. Ghosh & V. A. Raghunathan, Structure of Mesh Phases in a Cationic Surfactant System with Strongly Bound Counterions: Influence of the Surfactant head group and Counterions,Langmuir (2009), 25, 2622-2688

2. S. K. Ghosh, R. Ganpathy, R. Krishnaswamy, J. Bellare, V. A. Raghunathan & A. K. Sood, Structure of Mesh Phases in a Cationic Surfactant System with Strongly Bound Counterions.Langmuir (2007), 23, 3606-3614.

1. R. Krishnaswamy, S. K. Ghosh, S. Lakshmanan, V. A. Raghunathan & A. K. Sood, Phase Behaviour of a Concentrated Aqueous Solution of Cetyltrimethylammonium Bromide (CTAB) and Sodium Hydroxy Naphthoate (SHN), Langmuir (2005), 21, 10439-10443.

Conference Publications

6. P. Hitaishi and S. K. Ghosh, Effects of L-Phenylalanine on a Model Phospholipid Membrane, Proceedings of the DAE Solid State Physics Symposium, Page: 109-110, Vol. 55 (2021)

5. R. Gupta and S. K. Ghosh, Effects of violacein on the organization of lipids in a model cell membrane, Photon Factory Activity Report 2020#39(2021), Japan

4. S. Mitra, and S. K. Ghosh, Effect of ionic liquids on the structures of ripple phases of model cellular membranes, AIP Conference proceeding (2020) 2265, 030024.

3. R. Gupta and S.K. Ghosh, Co-existence of two lamellar phases in phospholipid multilayers induced by an ionic liquid, AIP Conference Proceeding (2020), 2265, 030032

2. S. Mitra, G. Bhattacharya and S. K. Ghosh, Quantifying the structural effects of ionic liquids on model cellular membrane, Photon Factory Activity Report 2018 #36 (2019), Japan

1. S. K. Ghosh et al., Interaction with synaptic vesicles induces structural changes in a lipid monolayer, European Synchrotron Radiation Facility (ESRF) Highlights, 2011, page: 51-52 

Journal Publications (submitted)

1. N. Kaur, M. Fischer, P. Hitaishi, S. Kumar, V. K. Sharma, S. K. Ghosh, G. K. Gahlay, H. A. Scheidt and V. Singh Mithu; How 1,n-Bis(3-alkylimidazolium-1-yl) alkane Interacts with the Phospholipid Membrane and Impacts the Toxicity of Dicationic Ionic Liquids

2. G. Sharma, S. Mitra, S. M. Kamil and S. K. Ghosh; Shear-induced phase transition in the aqueous solution of an imidazolium-based ionic liquid

Projects

  1. Title:Toxicity of Ionic liquids: Investigating with model cellular membrane
    Funding: UGC-DAE, Mumbai Centre
    Role: Principal Investigator (PI)
    Project Cost: 17 Lakhs (Approx.)
  2. Title: Biophysical study of forming and controlling nano-sized domain in model cellular membrane
    Funding: Scientific & Engineering Research Board (SERB), Gov. of India
    Role: Principal Investigator (PI)
    Project Cost: 35 Lakhs (Approx.)
  3. Title: Investigation of optical properties of Al2O3/ZrO2 nanocrystalline multilayers for ion beam dosimetry. Funding: Department of Atomic Energy (DAE), Board of Research in Nuclear Sciences (BRNS)
    Role: Co-Principal Investigator (Co-PI)
    Project Cost: 34.86 Lakhs.
  4. Title: Development of sensors for blast and blight diseases and stomatal activity measurement in rice (O. Sativa L.)                                                                                                                                                                                                                    Funding: National Agricultural Science Fund (NASF), ICAR                                                                                                                   Role: Co-Principal Investigator (Co-PI)                                                                                                                                                        Project Cost: ~68 Lakhs.